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Form Guide: In 14 games since March's back-to-back Premier League defeats, United have won 11 and drawn three games, ensuring an 18th league title and a berth in Rome. The final victory of that run came at Hull on Sunday, where Sir Alex Ferguson had the luxury of resting a hatful of players who are likely to start on Wednesday. Barcelona have also been resting players ever since they clinched their own domestic crown, meaning little can be read into successive La Liga defeats against Mallorca and Osasuna.

Ins and Outs: Suspension rules out Darren Fletcher for United, while Barca are hampered by the absence of banned defenders Eric Abidal and Daniel Alves. The Catalans are still closely monitoring the fitness of key duo Andrés Iniesta (thigh) and Thierry Henry (knee), with both players confident of featuring. Similarly hopeful of lining up at the Stadio Olimpico is United's Rio Ferdinand, who is on course to return from a calf injury

Star Man: Take your pick. The tie is inevitably being billed as a battle between Ballon D'Or holder Cristiano Ronaldo and pocket genius Lionel Messi, but rarely can a supporting cast have been so star-studded. Two teams packed full of potential match-winners.

Referee: Massimo Busacca will be the man in the middle. This will be the 44-year-old Swiss official's 33rd Champions League tie, with his last outing coming as United overcame Porto in Portugal.